Thrombolysis will continue to be the mainstay for acute stroke treatment, despite the recent revolution in neurointerventional clot retrieval. However, as there are ongoing limitations of thrombolysis of bleeding risk and reduced efficacy in large clots – what possible therapeutic advancements can complement or act as an adjuvant to thrombolysis? Neurointervention – effective, but limited […]
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Generally, the unit of randomization in a randomized clinical trial (RCT) is the individual participant (the patient). Occasionally, the unit of randomization can be a cluster, such as hospitals, schools, villages, etc. When randomizing large groups, the concept of cluster randomized trials (CRTs) has become increasingly common. Patient clusters are allocated to the intervention arms […]
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Cluster randomized trials (CRTs) is the concept of grouping individuals for randomization into a treatment or control group. The design is increasingly becoming more common when randomizing large groups. It also reduces bias as there are less decision making required from clinicians or nurses. A study to compare the effects of a patients head position […]
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The concept of grouping subjects for randomization is called cluster randomized trials (CRT) – this concept is becoming increasingly common when randomizing large groups. However, when CRTs involve interventions at a cluster level, informed consent from participants may not always be possible to obtain. As informed consent is a fundamental ethical requirement for clinical trials, […]
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An ongoing study in Australia is showing how computer games can help patients recovering from strokes, brain injuries, amputations and other conditions. The study is the largest trial of its kind to utilize computer gaming technology in rehabilitation. The George Institute’s Professor Cathie Sherrington is leading this study that is testing a wide range of […]
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Access to large markets where clinical trials that can investigate real patient needs, and do so in a rapid fashion, is invaluable for clinical research organisations. One such example of George Clinical rapid and access to huge markets took place in China, where diabetes patients numbered up to 90 million in 2010, and the most […]
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A recent article published in PharmAsia News highlighted the results of ground-breaking research, published in The New England Journal of Medicine (NEJM), that showed a lower dose of intravenous alteplase can reduce bleeds in the brain and improve survival rates in patients with acute ischemic stroke. While the results of ENCHANTED, a predominantly Asian study, […]
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